Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen.

@article{Inaba2008IdentificationOH,
  title={Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen.},
  author={Hiroaki Inaba and Motoyuki Tagashira and Daiki Honma and Tomomasa Kanda and Yurong Kou and Yasuyuki Ohtake and Atsuo Amano},
  journal={Biological & pharmaceutical bulletin},
  year={2008},
  volume={31 3},
  pages={527-30}
}
Chronic marginal periodontitis is a destructive inflammatory disease caused by an imbalance between bacterial virulence and host defense ability, resulting in eventual tooth exfoliation. Porphyromonas gingivalis, a major periodontal pathogen, triggers a series of cellular inflammatory responses including the production of prostaglandin E2 (PGE2), which causes periodontal destruction; thus, anti-inflammatory reagents are considered beneficial for periodontal therapy. In the present study, we… CONTINUE READING