Identification of homology in protein structure classification

  title={Identification of homology in protein structure classification},
  author={Sabine Dietmann and Liisa Holm},
  journal={Nature Structural Biology},
Structural biology and structural genomics are expected to produce many three-dimensional protein structures in the near future. Each new structure raises questions about its function and evolution. Correct functional and evolutionary classification of a new structure is difficult for distantly related proteins and error-prone using simple statistical scores based on sequence or structure similarity. Here we present an accurate numerical method for the identification of evolutionary… CONTINUE READING

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