Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

@inproceedings{Frana2017IdentificationOH,
  title={Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development},
  author={Camila Tenorio França and Michael T White and Wen-Qiang He and Jessica B. Hostetler and Jessica Brewster and Gabriel Frato and Indu Malhotra and Jakub Gruszczyk and Christ{\`e}le Huon and Enmoore Lin and Benson Kiniboro and Anjali Yadava and Peter Siba and Mary Galinski and Julie Healer and Chetan E. Chitnis and Alan F Cowman and Eizo Takashima and Tatsushi Tsuboi and Wai-Hong Tham and Rick M. Fairhurst and Julian C. Rayner and Christopher L King and Ivo Mueller},
  booktitle={eLife},
  year={2017}
}
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with… CONTINUE READING
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