Identification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymerase.

@article{Wunderlich2011IdentificationOH,
  title={Identification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymerase.},
  author={Kerstin Wunderlich and Mindaugas Juozapaitis and C Ranadheera and Ulrich Kessler and Arnold Martin and Jessica Eisel and Ulrike Beutling and Ronald M Frank and Martin Schwemmle},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 2},
  pages={696-702}
}
The influenza A virus polymerase complex, consisting of the subunits PB1, PB2, and PA, represents a promising target for the development of new antiviral drugs. We have previously demonstrated the feasibility of targeting the protein-protein interaction domain between PA and PB1 using peptides derived from the extreme N terminus of PB1 (amino acids [aa] 1 to 15), comprising the PA-binding domain of PB1. To increase the binding affinity of these peptides, we performed a systematic structure… CONTINUE READING