Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

@article{Chang1994IdentificationOH,
  title={Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.},
  author={Y. Chang and Ethel Cesarman and Melissa S. Pessin and F Lee and J Culpepper and Daniel M. Knowles and Patrick S. Moore},
  journal={Science},
  year={1994},
  volume={266 5192},
  pages={
          1865-9
        }
}
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and… Expand

Paper Mentions

Interventional Clinical Trial
Background: - KSHV inflammatory cytokine syndrome (KICS) is a newly recognized disease caused by Kaposi sarcoma-associated herpesvirus (KSHV). This virus can cause cancer… Expand
ConditionsHHV-8, KSHV, KSHV Inflammatory Cytokine Syndrome (KICS)
InterventionDrug, Other
Interventional Clinical Trial
Background: - Pomalidomide is a drug that can treat cancer through several mechanisms. It is taken by mouth (orally). Pomalidomide can help treat cancer by blocking certain factors that promote… Expand
ConditionsKaposi Sarcoma, Sarcoma, Kaposi
InterventionDrug
Observational Clinical Trial
This study will try to identify new or known viruses responsible for diseases or conditions of unknown cause. Viruses are an important cause of illness. They have been identified as… Expand
ConditionsViral Diseases
Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma.
TLDR
The data support the view that a novel gamma herpesvirus might be specifically associated with Kaposi's sarcoma etiopathogenesis. Expand
Herpesvirus-like DNA sequences in Japanese patients with AIDS-related kaposi's sarcoma
  • N. Tachikawa, M. Goto, +5 authors A. Iwamoto
  • Biology, Medicine
  • Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • 1996
TLDR
Examination of three Japanese patients for presence of the KS-associated herpesvirus-like (KSHV) sequences shows the presence of KSHV in KS lesions and support its role in the pathogenesis of KS. Expand
Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma
TLDR
The results reinforce the hypothesis that an infectious agent closely related to gamma-herpesvirus is implicated in the pathogenesis of Mediterranean and AIDS-associated Kaposi's sarcoma. Expand
Short report: herpes-like DNA sequences in African-endemic and acquired immunodeficiency syndrome-associated Kaposi's sarcoma.
TLDR
The presence of herpes-like DNA sequences in six cases of AIDS-associated KS and three of the nine cases of African-endemic KS in adults, but not in eight cases of KS in children from the same area is confirmed. Expand
Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma
TLDR
The association between a new human herpesvirus-like agent and various forms of Kaposi's sarcoma was examined by PCR and the presence and expression of the virus was detected in some Kapos's tumours by Southern and northern blotting. Expand
Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients
TLDR
The results suggest that KSHV is associated with lesions other than KS in non-AIDS immunocompromised patients, and may also be involved in the pathogenesis of the various forms of proliferative skin lesions from organ-transplant patients. Expand
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.
TLDR
A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas. Expand
KAPOSI’S SARCOMA–ASSOCIATED HERPESVIRUS-LIKE DNA SEQUENCES IN AIDS-RELATED BODY-CAVITY–BASED LYMPHOMAS
Background. DNA fragments that appeared to belong to an unidentified human herpesvirus were recently found in more than 90 percent of Kaposi’s sarcoma lesions associated with the acquiredExpand
Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines.
TLDR
It is shown that malignant KS cell lines do not harbor herpesvirus-like DNA sequences while B cells, CD14+ and CD34+ cells do, suggesting that if a KS malignancy originates from infection with HHV-8, the virus can be lost and is not necessary for maintenance of the neoplastic state. Expand
Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma
TLDR
Results of screening DNA samples from isolated peripheral blood mononuclear cells (PBMCs) show that DNA was directly purified from uncultured PBMCs that were not infected with herpesvirus-like DNA sequence. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Possible cofactors for the development of AIDS-related neoplasms.
TLDR
Investigations of a suggested association between EBV and AIDS-associated non-Hodgkin's (B cell) lymphomas (NHLs) have been inconclusive, but HIV may act as a cofactor in accelerating the development of hepatitis B-associated hepatocellular carcinoma. Expand
CYTOMEGALOVIRUS AND KAPOSI'S SARCOMA IN YOUNG HOMOSEXUAL MEN
TLDR
Observations suggest an association of CMV with Kaposi's sarcoma, and IgG and IgM antibodies to CMV were detected in 9 out of 9 patients, and normal tissue specimens from 3 KS patients were negative for CMV antigen. Expand
Implausibility of an aetiological association between cytomegalovirus and Kaposi's sarcoma shown by four techniques.
TLDR
There did not seem to be any association between the presence of CMV and the occurrence of Kaposi's sarcoma in patients with AIDS, and the various detection methods correlated very well. Expand
Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?
TLDR
Kaposi's sarcoma in persons with AIDS may be caused by an as yet unidentified infectious agent, transmitted mainly by sexual contact. Expand
Mycoplasma penetrans infection in male homosexuals with AIDS: high seroprevalence and association with Kaposi's sarcoma.
  • R. Wang, J. Shih, +7 authors R. Mayur
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1993
TLDR
Antibodies to Mycoplasma penetrans were found at an unusually high frequency in male homosexuals with AIDS and in human immunodeficiency virus (HIV)-infected asymptomatic homosexuals but not in intravenous drug users and hemophiliacs with or without HIV-1 infection. Expand
Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome.
TLDR
The risk of having another cancer following Kaposi's sarcoma was increased only in persons infected with human immunodeficiency virus, who were at high risk of non-Hodgkin's lymphoma but probably not of other cancers as a whole. Expand
Is risk of Kaposi's sarcoma in AIDS patients in Britain increased if sexual partners came from United States or Africa?
TLDR
The data suggest that Kaposi's sarcoma is caused by a sexually transmissible agent which was introduced into the British homosexual population mainly from the United States. Expand
Cytomegalovirus (CMV) titers among acquired immunodeficiency syndrome (AIDS) patients with and without a history of Kaposi's sarcoma (KS).
TLDR
Serologic data failed to demonstrate a role for CMV infection in the pathogenesis of KS and serum titers to cytomegalovirus among homosexual patients with acquired immunodeficiency syndrome (AIDS) did not differ with respect to the distribution of CMV titers. Expand
Mycoplasma penetrans sp. nov., from the urogenital tract of patients with AIDS.
  • S. Lo, M. Hayes, +5 authors J. Shih
  • Biology, Medicine
  • International journal of systematic bacteriology
  • 1992
TLDR
An unusual mycoplasma, which was isolated from the urine of a human immunodeficiency virus-positive male homosexual patient, has an elongated flask shape and two unique sharply divided internal compartments, and it is proposed that this new mollicute species should be named MyCoplasma penetrans sp. Expand
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein–Barr virus has been established using the dideoxynucleotide/M13 sequencing procedure. Many RNA polymerase IIExpand
...
1
2
3
...