Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype.

@article{Jin2003IdentificationOH,
  title={Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype.},
  author={Ling Jin and Weiping Peng and Guey-chuen Perng and David J. Brick and Anthony B. Nesburn and Clinton Jones and Steven L Wechsler},
  journal={Journal of virology},
  year={2003},
  volume={77 11},
  pages={6556-61}
}
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation phenotype of HSV-1 in the rabbit ocular model and for the high induced reactivation phenotype in the mouse ocular model. Recently we showed that LAT has an antiapoptosis function, and we hypothesized that LAT's ability to inhibit apoptosis played an important role in LAT's ability to enhance the reactivation phenotype. Expression of just the first 1.5… CONTINUE READING

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