Identification of grass carp IL-10 receptor subunits: functional evidence for IL-10 signaling in teleost immunity.

@article{Wei2014IdentificationOG,
  title={Identification of grass carp IL-10 receptor subunits: functional evidence for IL-10 signaling in teleost immunity.},
  author={He Wei and Xinyan Wang and Anying Zhang and Linyong Du and Hong Zhou},
  journal={Developmental and comparative immunology},
  year={2014},
  volume={45 2},
  pages={259-68}
}
Although the functions of teleost IL-10 have been preliminarily determined, functional evidence for its receptor signaling is lacking. Particularly, the identity of fish IL-10 receptor 2 (IL-10R2) is ambiguous. Cytokine receptor family member b4 (CRFB4) and CRFB5 are likely the ortholog of mammalian IL-10R2. In this study, grass carp CRFB4 (gcCRFB4) and gcCRFB5 cDNAs were isolated and characterized. The relatively high expression levels of grass carp IL10 receptor 1 (gcIL-10R1), gcCRFB4 and… CONTINUE READING

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