Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells.

Abstract

Resistance to tubulin-binding agents used in cancer is often multifactorial and can include changes in drug accumulation and modified expression of tubulin isotypes. Glycans on cell membrane proteins play important roles in many cellular processes such as recognition and apoptosis, and this study investigated whether changes to the glycan structures on cell… (More)
DOI: 10.1074/mcp.M111.009001

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