Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription.

@article{Tang2009IdentificationOG,
  title={Identification of glucose-regulated miRNAs from pancreatic \{beta\} cells reveals a role for miR-30d in insulin transcription.},
  author={Xiaoqing Tang and Latha Muniappan and Guiliang Tang and Sabire Ozcan},
  journal={RNA},
  year={2009},
  volume={15 2},
  pages={
          287-93
        }
}
MicroRNAs (miRNAs) are small noncoding ribonucleotides that bind mRNAs and function mainly as translational repressors in mammals. MicroRNAs have been implicated to play a role in many diseases, including diabetes. Several reports indicate an important function for miRNAs in insulin production as well as insulin secretion. We have recently carried out a screen in the pancreatic beta-cell line MIN6 to identify miRNAs with altered abundance in response to changes in glucose concentrations. This… CONTINUE READING

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