Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat.

@article{Schmidt2009IdentificationOG,
  title={Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat.},
  author={Jonathan A. Schmidt and Mary R. Avarbock and John W Tobias and Ralph L. Brinster},
  journal={Biology of reproduction},
  year={2009},
  volume={81 1},
  pages={56-66}
}
Spermatogonial stem cells (SSCs) provide the foundation for spermatogenesis throughout the life of a male. Because SSCs of many species can colonize the mouse testis, and glial cell line-derived neurotrophic factor (GDNF) is responsible for stimulating SSC self-renewal in rodents, we reasoned that molecular mechanisms of SSC self-renewal are similar across species. GDNF-regulated genes have been identified in mouse SSCs; however, downstream targets of GDNF are unknown in other species. The… CONTINUE READING
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