Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)

@inproceedings{Tram2011IdentificationOG,
  title={Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)},
  author={Eric Tram and Irada Ibrahim-zada and Laurent Briollais and J. A. G. Knight and Irene L Andrulis and Hilmi Ozçelik},
  booktitle={Breast Cancer Research},
  year={2011}
}
A common feature of neoplastic cells is that mutations in SMADs can contribute to the loss of sensitivity to the anti-tumor effects of transforming growth factor-β (TGF-β). However, germline mutation analysis of SMAD3 and SMAD4, the principle substrates of the TGF-β signaling pathway, has not yet been conducted in breast cancer. Thus, it is currently unknown whether germline SMAD3 and SMAD4 mutations are involved in breast cancer predisposition. We performed mutation analysis of the highly… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Gene expression profiling of peripheral blood cells for early detection of breast cancer

  • J Aaroe, T Lindahl, +7 authors AL Borresen-Dale
  • Breast Cancer Res
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…