Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2)

  title={Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2)},
  author={S. Breidenthal and D. J. White and C. Glatt},
  journal={Psychiatric Genetics},
Objective We screened the complete protein coding sequence of the newly identified neuronal form of tryptophan hydroxylase (TPH2) for genetic variants. Methods Genomic DNA samples from 24 African-Americans and 24 Caucasian-Americans in the Coriell human variation collection were screened by denaturing high-performance liquid chromatography followed by sequencing. Results We identified a number of genetic variants in both the coding and exon-flanking intronic sequences. Only one variant was… Expand
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