Identification of genetic variants associated with response to statin therapy.

  title={Identification of genetic variants associated with response to statin therapy.},
  author={Jessica L. Mega and David A. Morrow and Alison C Brown and Christopher Paul Cannon and Marc S. Sabatine},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={29 9},
OBJECTIVE The purpose of this study was to test the association between polymorphisms in genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics and LDL-C reduction with statins. METHODS AND RESULTS 49 tagging and candidate polymorphisms in 9 genes were genotyped in 1507 post-ACS subjects randomized to atorvastatin or pravastatin. Two polymorphisms (rs7412, rs429358) that define the epsilon2, epsilon3, and epsilon4 isoforms of apolipoprotein E were significantly… CONTINUE READING


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