Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.

@article{Harries1997IdentificationOG,
  title={Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.},
  author={Lorna W Harries and Michael James Stubbins and Danial Forman and Gary C. Howard and C. R. Wolf},
  journal={Carcinogenesis},
  year={1997},
  volume={18 4},
  pages={
          641-4
        }
}
Two variant glutathione S-transferase cDNAs have been described at the GSTP1 locus, which differ by a single base pair (A-G) substitution at nucleotide 313 of the GSTP1 cDNA. This results in an amino acid substitution which alters the function of the enzyme. In this study, a novel PCR assay has been developed which demonstrates that these two variant cDNAs represent distinct GSTP1 alleles (GSTP1a and GSTP1b). In a study of individuals with different forms of cancer, the GSTP1b allele is found… CONTINUE READING

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