Identification of genetic mutations associated with attenuation and changes in tropism of Urabe mumps virus.

@article{Shah2009IdentificationOG,
  title={Identification of genetic mutations associated with attenuation and changes in tropism of Urabe mumps virus.},
  author={Dion Shah and S{\'i}lvia Vidal and Malen A. Link and Steven A. Rubin and Kathryn E Wright},
  journal={Journal of medical virology},
  year={2009},
  volume={81 1},
  pages={130-8}
}
Although several effective mumps virus vaccines have been developed, almost nothing is known about the genetic changes responsible for loss of virulence. One vaccine, Urabe AM9, was withdrawn from the market because of insufficient attenuation. The vaccine was found to contain a mixture of viruses that could be distinguished based on the sequence of the… CONTINUE READING