Identification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicity.

@article{Mitzel2008IdentificationOG,
  title={Identification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicity.},
  author={Dana N. Mitzel and Sonja M. Best and Max F Masnick and Stephen F Porcella and James B. Wolfinbarger and Marshall E. Bloom},
  journal={Virology},
  year={2008},
  volume={381 2},
  pages={268-76}
}
Tick-borne flaviviruses are maintained in nature in an enzootic cycle involving a tick vector and a vertebrate host. Thus, the virus replicates in two disparate hosts, each providing selective pressures that can influence virus replication and pathogenicity. To identify viral determinants associated with replication in the individual hosts, plaque purified Langat virus (TP21pp) was adapted to growth in mouse or tick cell lines to generate two virus variants, MNBp20 and ISEp20, respectively… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…