Identification of genes that are essential to restrict genome duplication to once per cell division

@inproceedings{Vassilev2016IdentificationOG,
  title={Identification of genes that are essential to restrict genome duplication to once per cell division},
  author={Alex P Vassilev and Chrissie Y. Lee and Boris Vassilev and Wenge Zhu and Pinar Ormanoglu and Scott E. Martin and Melvin L Depamphilis},
  booktitle={Oncotarget},
  year={2016}
}
Nuclear genome duplication is normally restricted to once per cell division, but aberrant events that allow excess DNA replication (EDR) promote genomic instability and aneuploidy, both of which are characteristics of cancer development. Here we provide the first comprehensive identification of genes that are essential to restrict genome duplication to once per cell division. An siRNA library of 21,584 human genes was screened for those that prevent EDR in cancer cells with undetectable… CONTINUE READING
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