Identification of genes that affect sensitivity to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae

@article{Fujii2010IdentificationOG,
  title={Identification of genes that affect sensitivity to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae},
  author={Michihiko Fujii and Kensuke Miki and Shinichi Takayama and Dai Ayusawa},
  journal={Molecular Genetics and Genomics},
  year={2010},
  volume={283},
  pages={461-468}
}
Small molecules that exhibit biological effects have been successfully used to study various biological phenomena. 5-Bromodeoxyuridine (BrdU) is a thymidine analog that affects various biological processes, such as cellular differentiation and cellular senescence in cultured mammalian cells. Although BrdU is thought to modulate these phenomena by changing chromatin structure and gene expression, the molecular mechanisms for the action of BrdU are not understood well. To analyze the molecular… CONTINUE READING
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