Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.

@article{Reddien2005IdentificationOG,
  title={Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.},
  author={Peter W Reddien and Adam L Bermange and Kenneth J. Murfitt and J. R. Jennings and Alejandro S{\'a}nchez Alvarado},
  journal={Developmental cell},
  year={2005},
  volume={8 5},
  pages={635-49}
}
Planarians have been a classic model system for the study of regeneration, tissue homeostasis, and stem cell biology for over a century, but they have not historically been accessible to extensive genetic manipulation. Here we utilize RNA-mediated genetic interference (RNAi) to introduce large-scale gene inhibition studies to the classic planarian system. 1065 genes were screened. Phenotypes associated with the RNAi of 240 genes identify many specific defects in the process of regeneration and… CONTINUE READING
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