Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium.

@article{Smith2001IdentificationOG,
  title={Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium.},
  author={Barbara A. Smith and W. J. Kennedy and Patricia M Harnden and Peter John Selby and Ludwik K. Trejdosiewicz and Jennifer Southgate},
  journal={Cancer research},
  year={2001},
  volume={61 4},
  pages={1678-85}
}
Interactions between epithelial cells and the extracellular matrix are central to tissue homeostasis and have a dynamic role in tissue remodeling and repair. Regulation of these pathways is balanced by positive and negative feedback elements, many of which have been implicated in the pathways of malignant progression. We have used differential display to identify genes that are up-regulated in normal human urothelial cells in response to exposure to extracellular matrix proteins (Matrigel) in… CONTINUE READING

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