Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants

  title={Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants},
  author={Vanya D. Peltekova and Mathieu F. Lemire and Aamer Mahmood Qazi and Syed Hassan Ejaz Zaidi and Quang Minh Trinh and Ryszard Bielecki and Marianne Rogers and Lyndsey Hodgson and Mike Kwan Wing Wang and David J A D’Souza and Sasan Zandi and Taryne Chong and Jennifer Y. Y. Kwan and Krystian Kozak and Richard de Borja and Lee Timms and Jagadish Rangrej and Milica Volar and Michelle A. Chan-Seng-Yue and Timothy A Beck and Colleen Ash and S. J. Patrick Lee and Jianxin Wang and Paul C. Boutros and Lincoln D. Stein and John E Dick and Robert Gryfe and John D. McPherson and Brent W. Zanke and Aaron Pollett and Steven Gallinger and Thomas J. Hudson},
  booktitle={International journal of cancer},
A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this locus that are related to the etiopathology of CRC, we used microarray-based target selection methods, coupled to next-generation sequencing, to study 103 kb at the 11q23 locus. We genotyped 369 putative variants from 1,030 patients with CRC… CONTINUE READING
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