Identification of genes encoding mouse oocyte secretory and transmembrane proteins by a signal sequence trap.

@article{Taft2002IdentificationOG,
  title={Identification of genes encoding mouse oocyte secretory and transmembrane proteins by a signal sequence trap.},
  author={Robert A. Taft and James M Denegre and Frank L Pendola and John J. Eppig},
  journal={Biology of reproduction},
  year={2002},
  volume={67 3},
  pages={953-60}
}
The oocyte plays a key role in follicular development. At all stages of follicular development, oocytes interact with surrounding granulosa cells and promote their differentiation into the types of cells that support further oocyte growth and developmental competence. These interactions suggest the existence of an oocyte-granulosa cell regulatory loop that includes both secreted proteins and cell surface receptors on both cell types. Factors involved in the regulatory loop will therefore… CONTINUE READING

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