Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.

Abstract

Mammalian liver contains a pregnane X receptor (PXR, NR1I2), which binds drugs and other xenobiotics, and stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substances. In the present study, we used microarray analysis to identify genes whose expression in rat liver… (More)

Topics

Cite this paper

@article{Guzelian2006IdentificationOG, title={Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.}, author={Jeffrey P. Guzelian and Joyce L Barwick and Lawrence Hunter and Tzu L. Phang and Linda C. Quattrochi and Philip S. Guzelian}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2006}, volume={94 2}, pages={379-87} }