Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis.

@article{Chakraborty2007IdentificationOG,
  title={Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis.},
  author={Sanjukta Chakraborty and Sonal Khare and Syril Dorairaj and Venkatesh C. Prabhakaran and Durgappa Ravi Prakash and Arun Kumar},
  journal={Genomics},
  year={2007},
  volume={90 3},
  pages={344-53}
}
There is no report on the gene expression profile of retinoblastoma (Rb). We analyzed the gene expression profile of Rb by the microarray technique. One thousand four genes were upregulated and 481 genes were downregulated. Microarray data were confirmed by semiquantitative RT-PCR for 5 genes in Rb samples: CDC25A, C17orf75, ERBB3, LATS2, and CHFR. Clusters of differentially expressed genes were identified on chromosomes 1, 16, and 17. Based on the expression profile, we hypothesized that the… CONTINUE READING

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