Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer

@inproceedings{Leffers2010IdentificationOG,
  title={Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer},
  author={Ninke Leffers and Rudolf S. N. Fehrmann and Marloes J. M. Gooden and Ute R Schulze and Klaske A. ten Hoor and Harry Hollema and H. Marieke Boezen and Toos Daemen and Steven de Jong and Hans W Nijman and Ate G. J. van der Zee},
  booktitle={British Journal of Cancer},
  year={2010}
}
Background:Tumour-infiltrating lymphocytes (TILs) are predictors of disease-specific survival (DSS) in ovarian cancer. It is largely unknown what factors contribute to lymphocyte recruitment. Our aim was to evaluate genes and pathways contributing to infiltration of cytotoxic T lymphocytes (CTLs) in advanced-stage serous ovarian cancer.Methods:For this study global gene expression was compared between low TIL (n=25) and high TIL tumours (n=24). The differences in gene expression were evaluated… CONTINUE READING

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Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer.

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Highly Influenced

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