Identification of genes, including the gene encoding p27Kip1, regulated by serine 276 phosphorylation of the p65 subunit of NF-kappaB.

@article{Prasad2009IdentificationOG,
  title={Identification of genes, including the gene encoding p27Kip1, regulated by serine 276 phosphorylation of the p65 subunit of NF-kappaB.},
  author={Ratna Chakraborty Prasad and Xiaohui L Wang and Brian Keith Law and Bradley M. Davis and Gail Green and Braden E. Boone and Lauren V. Sims and Mary Business Law},
  journal={Cancer letters},
  year={2009},
  volume={275 1},
  pages={
          139-49
        }
}
Phosphorylation of the p65 subunit of NF-kappaB is required for its transcriptional activity. Recent reports show that phosphorylation of p65 at serine 276 regulates only a subset of genes, such as those encoding IL-6, IL-8, Gro-beta, and ICAM-1. In order to identify additional genes regulated by serine 276 phosphorylation, HepG2 hepatoma cells were infected with adenoviruses encoding either wild-type p65 or the S276A mutant of p65, followed by DNA microarray analysis. The results show that… CONTINUE READING

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