Identification of gene interactions associated with disease from gene expression data using synergy networks

@article{Watkinson2007IdentificationOG,
  title={Identification of gene interactions associated with disease from gene expression data using synergy networks},
  author={John Watkinson and Xiaodong Wang and Tian Zheng and Dimitris Anastassiou},
  journal={BMC Systems Biology},
  year={2007},
  volume={2},
  pages={10 - 10}
}
Analysis of microarray data has been used for the inference of gene-gene interactions. If, however, the aim is the discovery of disease-related biological mechanisms, then the criterion for defining such interactions must be specifically linked to disease. Here we present a computational methodology that jointly analyzes two sets of microarray data, one in the presence and one in the absence of a disease, identifying gene pairs whose correlation with disease is due to cooperative, rather than… CONTINUE READING
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