Identification of gene 4 alleles among human rotaviruses by polymerase chain reaction-derived probes.

@article{Larralde1990IdentificationOG,
  title={Identification of gene 4 alleles among human rotaviruses by polymerase chain reaction-derived probes.},
  author={Gisela Larralde and Jorge Flores},
  journal={Virology},
  year={1990},
  volume={179 1},
  pages={469-73}
}
Four different alleles of the gene encoding VP4, an outer capsid rotavirus protein, have been recognized among human rotaviruses. To investigate the relative frequency of these alleles, hybridization probes corresponding to a hyperdivergent region (nucleotides 205 to 554) of the fourth gene from three human rotavirus strains, Wa, DS1, and M37 (each of which has a distinct gene four allele), were synthesized by the polymerase chain reaction (PCR) method, using as templates either cloned DNA or… CONTINUE READING

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