Identification of gene 3' ends by automated EST cluster analysis.

  title={Identification of gene 3' ends by automated EST cluster analysis.},
  author={Enrique M. Muro and Robert Herrington and Salima Janmohamed and Catherine Frelin and Miguel A. Andrade-Navarro and Norman N. Iscove},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 51},
The properties and biology of mRNA transcripts can be affected profoundly by the choice of alternative polyadenylation sites, making definition of the 3' ends of transcripts essential for understanding their regulation. Here we show that 22-52% of sequences in commonly used human and murine "full-length" transcript databases may not currently end at bona fide polyadenylation sites. To identify probable transcript termini over the entire murine and human genomes, we analyzed the EST databases… CONTINUE READING

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