Identification of functional type 1 ryanodine receptors in mouse dendritic cells.

@article{OConnell2002IdentificationOF,
  title={Identification of functional type 1 ryanodine receptors in mouse dendritic cells.},
  author={Peta J O'Connell and Vitaly A. Klyachko and Gerard P. Ahern},
  journal={FEBS letters},
  year={2002},
  volume={512 1-3},
  pages={67-70}
}
Ca(2+) signaling plays an important role in the function of dendritic cells (DC), the specialized antigen-presenting cells of the immune system. Here we describe functional ryanodine receptor (RyR) Ca(2+) release channels in murine, bone marrow-derived DC. RT-PCR analysis identified selective expression of the type 1 RyR, with higher levels detected in immature rather than mature DC. The RyR activators caffeine, FK506, ryanodine and 4-chloro-m-cresol mobilized Ca(2+) in DC, and responses to 4… CONTINUE READING
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