Identification of functional residues essential for dehalogenation by the non-stereospecific α-haloalkanoic acid dehalogenase from Rhizobium sp. RC1.

@article{Hamid2015IdentificationOF,
  title={Identification of functional residues essential for dehalogenation by the non-stereospecific α-haloalkanoic acid dehalogenase from Rhizobium sp. RC1.},
  author={Azzmer Azzar Abdul Hamid and Tengku Abdul Hamid and Roswanira Abdul Wahab and Fahrul Huyop},
  journal={Journal of basic microbiology},
  year={2015},
  volume={55 3},
  pages={
          324-30
        }
}
The non-stereospecific α-haloalkanoic acid dehalogenase DehE from Rhizobium sp. RC1 catalyzes the removal of the halide from α-haloalkanoic acid D,L-stereoisomers and, by doing so, converts them into hydroxyalkanoic acid L,D-stereoisomers, respectively. DehE has been extensively studied to determine its potential to act as a bioremediation agent, but its structure/function relationship has not been characterized. For this study, we explored the functional relevance of several putative active… CONTINUE READING
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