Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.

Abstract

Caspases are central to apoptosis, and the principal executioner caspases, caspase-3 and -7, were reported to be similar in activity, primary structure, and three-dimensional structure. Here, we identified different activity in caspase-3 and -7 within cells and examined the relationship between their structure and function using human cells expressing… (More)
DOI: 10.1074/jbc.M110.126573

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