Identification of functional networks associated with cell death in the retina of OXYS rats during the development of retinopathy.

@article{Telegina2015IdentificationOF,
  title={Identification of functional networks associated with cell death in the retina of OXYS rats during the development of retinopathy.},
  author={Darya V. Telegina and Elena E Korbolina and Nikita I. Ershov and Nataliya G. Kolosova and Oyuna S. Kozhevnikova},
  journal={Cell cycle},
  year={2015},
  volume={14 22},
  pages={3544-56}
}
Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of early events in AMD is poorly understood. Senescence-accelerated OXYS rats develop AMD-like retinopathy. The aim of this study was to explore the differences in retinal gene expression between OXYS and Wistar (control) rats at age 20 d and to identify the pathways of retinal cell death involved in the OXYS retinopathy initiation and progression. Retinal mRNA profiles of… CONTINUE READING