Identification of four genes as novel susceptibility loci for early-onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia

  title={Identification of four genes as novel susceptibility loci for early-onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia},
  author={Yoshiji Yamada and Kimihiko Kato and Mitsutoshi Oguri and Hideki Horibe and Tetsuo Fujimaki and Yoshiki Yasukochi and Ichiro Takeuchi and Jun Sakuma},
  journal={Biomedical Reports},
  pages={21 - 36}
Given that early-onset type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), and hyperuricemia have been shown to have strong genetic components, the statistical power of a genetic association study may be increased by focusing on early-onset subjects with these conditions. Although genome-wide association studies have identified various genes and loci significantly associated with T2DM, MetS, and hyperuricemia, genetic variants that contribute to predisposition to these conditions in… 

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