Identification of four allelic variants of the dog IGHA gene

Multiple IgA subclasses have been identified in humans, primates and lagomorphs, whereas in mice, cattle and dogs only a single subclass has been identified. The two human subclasses (IgA1 and IgA2) are defined by a difference in the length of the hinge region of the α chains between the CH1 and CH2 domains. The single IgA subclass so far identified in dogs… CONTINUE READING