Identification of formyl Met-Leu-Phe in culture filtrates of Helicobacter pylori.

Abstract

Helicobacter pylori synthesizes and secretes a substance which co-chromatographs and is antigenically cross-reactive with the bacterial chemotactic peptide fMet-Leu-Phe. Using reverse phase and affinity chromatography this substance has now been purified. Carboxypeptidase Y microsequencing has verified that this material is fMet-Leu-Phe. The infiltration of polymorphonuclear leucocytes to sites of H. pylori infection may be a response to mucosal permeation of soluble, diffusable bioreactive substances such as fMet-Leu-Phe.

Cite this paper

@article{Broom1992IdentificationOF, title={Identification of formyl Met-Leu-Phe in culture filtrates of Helicobacter pylori.}, author={Murray F. Broom and Robert Sherriff and D J Munster and Vinton S. Chadwick}, journal={Microbios}, year={1992}, volume={72 292-293}, pages={239-45} }