Identification of follistatin-like 1 by expression cloning as an activator of the growth differentiation factor 15 gene and a prognostic biomarker in acute coronary syndrome.

@article{Widera2012IdentificationOF,
  title={Identification of follistatin-like 1 by expression cloning as an activator of the growth differentiation factor 15 gene and a prognostic biomarker in acute coronary syndrome.},
  author={Christian Widera and Evangelos Giannitsis and T. Kempf and Mortimer Korf-Klingebiel and Beate Fiedler and Sarita Sharma and Hugo A. Katus and Yasuhide Asaumi and Masayuki Shimano and Kenneth Walsh and Kai C. Wollert},
  journal={Clinical chemistry},
  year={2012},
  volume={58 8},
  pages={1233-41}
}
BACKGROUND Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine and biomarker that is produced after myocardial infarction and that is related to prognosis in acute coronary syndrome (ACS). We hypothesized that secreted proteins that activate GDF15 production may represent new ACS biomarkers. METHODS We expressed clones from an infarcted mouse heart cDNA library in COS1 cells and assayed for activation of a luciferase reporter gene controlled by a 642-bp fragment of the… CONTINUE READING
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