Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater

  title={Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater},
  author={Andreas Hartmann and A. Alder and T. Koller and R. Widmer},
  journal={Environmental Toxicology and Chemistry},
  • Andreas Hartmann, A. Alder, +1 author R. Widmer
  • Published 1998
  • Chemistry
  • Environmental Toxicology and Chemistry
  • Previous work revealed genotoxic effects in the wastewater of a large university hospital using a bacterial short-term genotoxicity assay, based on a umuC::lacZ fusion gene (umuC assay). These studies ruled out disinfectants and detergents as main causative agents of the genotoxic effects. This paper focuses on specific hospital-related drugs as the cause. The ratio of theoretical mean wastewater concentrations (derived from consumption data) and lowest observable effect concentrations of… CONTINUE READING
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