Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater

  title={Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater},
  author={Andreas Hartmann and Alfredo C. Alder and Th. Koller and Rosa M. Widmer},
  journal={Environmental Toxicology and Chemistry},
Previous work revealed genotoxic effects in the wastewater of a large university hospital using a bacterial short‐term genotoxicity assay, based on a umuC::lacZ fusion gene (umuC assay). These studies ruled out disinfectants and detergents as main causative agents of the genotoxic effects. This paper focuses on specific hospital‐related drugs as the cause. The ratio of theoretical mean wastewater concentrations (derived from consumption data) and lowest observable effect concentrations of… 

Primary DNA Damage But Not Mutagenicity Correlates with Ciprofloxacin Concentrations in German Hospital Wastewaters

Positive umuC results in hospital wastewater are strongly dependent on the presence of fluoroquinolone antibiotics, and previously generated Ames and V79 chromosomal aberration data were compared with the newly generated results, indicating the existence of additional mutagens that are yet to be identified.

Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam

Occurrence and behavior of fluoroquinolone antibacterial agents (FQs) were investigated in hospital wastewaters in Hanoi, Vietnam. Hospital wastewater in Hanoi is usually not treated and this

Hospital wastewater genotoxicity.

This work shows that this hospital wastewaters samples are very often genotoxic, the response intensity being inflected by rain levels.

Ecotoxicological and Genotoxic Evaluation of Buenos Aires City (Argentina) Hospital Wastewater

The need for environmental control programs and the establishment of advanced and effective effluent treatment plants in the hospitals, which are merely dumping the wastewaters in the municipal sewerage system, is highlighted.



Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

The SOS Chromotest is sufficiently sensitive to screen for the presence of soluble DNA-damaging agents in a wide variety of unconcentrated wastewater samples, indicating that soluble genotoxicants are relatively recalcitrant to oxidation.

Detection of genotoxic activity in native hospital waste water by the umuC test.

Mutagenicity of Quinolone Antibacterials

Results of carcinogenicity studies conducted to date with the quinolone antibacterials suggest minimal risk from long term consumption of the newer, second-generation compounds.

Genotoxicity of Organic Substances in Municipal Sewage and Its Ozonated Products

Some organic substances contaminated in industrial wastewaters are not easily decomposed through biological treatment plant. In order to investigate the genotoxicity of the substances which remain in

Comparing the presence, potency, and potential hazard of genotoxins extracted from a broad range of industrial effluents

Overall, the results suggest that pulp and paper mills emit mostly soluble genotoxins, while petroleum and aluminum refineries emit predominantly particle‐associated genOToxins.

Norfloxacin binds to human fecal material

The finding of the present study indicated that binding of norfloxacin to feces may explain the paradox of high fecal concentrations of nor FLXacin versus the actual effect on the normal gastrointestinal microflora.

Validation of the SOS/Umu test with mutagenic complex mixtures.

Effects of new quinolone antibacterial agents on mammalian chromosomes.

  • H. ShimadaS. Itoh
  • Biology, Chemistry
    Journal of toxicology and environmental health
  • 1996
Clastogenic effects of several new quinolones were studied cytogenetically using Chinese hamster lung cells (CHL) and the mouse micronucleus test and the lack of concordance between in vitro and in vivo assays could reflect the differences in the tissue levels of the drugs and the in vitro conditions.

Cytotoxic drugs and the aquatic environment: estimation of bleomycin in river and water samples

The risk to human health of ingesting water (in SE England) with such low levels of this cytotoxic drug appears to be minimal in relation to the normal chemotherapeutic doses administered.

Toxicity of quinolone antimicrobial agents.

This review concentrates on a description of the known effects of quinolones on various organ systems in experimental animals and humans, and it is questionable whether these drugs share similar safety and efficacy.