Identification of fifteen new psoriasis susceptibility loci highlights the role of innate immunity

Abstract

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of three genome-wide association studies (GWAS) and two independent datasets genotyped on the Immunochip, involving 10,588 cases and 22,806 controls in total. We identified 15 new disease susceptibility regions, increasing the number of psoriasis-associated loci… (More)

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@inproceedings{Tsoi2012IdentificationOF, title={Identification of fifteen new psoriasis susceptibility loci highlights the role of innate immunity}, author={Lam C. Tsoi and Sarah L Spain and Jo Knight and Eva Ellinghaus and Philip E Stuart and Francesca Capon and Jun Ding and Yanming Li and T. Naga Sai Tejasvi and Johann Eli Gudj{\'o}nsson and Hyun Mo Kang and Michael Hugh Allen and Ross McManus and Giuseppe Novelli and Lena Samuelsson and Joost Schalkwijk and Mona St{\aa}hle and A. David Burden and Catherine H Smith and Michael J Cork and Xavier Estivill and Anne M Bowcock and G. Kr{\"u}ger and Wolfgang Weger and Jane Worthington and Rachid Tazi-Ahnini and Frank O. Nestle and Adrian C. Hayday and Per Hoffmann and Juliane Winkelmann and Cisca Wijmenga and Cordelia Langford and S. Edkins and Robert Andrews and Hannah Blackburn and Amy Strange and Gavin Band and Richard D. Pearson and Damjan Vukcevic and Chris Ca Spencer and Panos Deloukas and Ulrich Mrowietz and Stefan Schreiber and Stephan Ernst Weidinger and Sulev K{\~o}ks and K{\"u}lli Kingo and T{\~o}nu Esko and Andres Metspalu and Henry W. Lim and John J . Voorhees and Michael Weichenthal and H. E. Wichmann and Vinod Chandran and Cheryl F. Rosen and Proton Rahman and Dafna D Gladman and Christopher Griffiths and Andr{\'e} Reis and Juha Kere and Rajan P. Nair and Andre Franke and Jonathan N W N Barker and Gonçalo R. Abecasis and James T. Elder and Richard C Trembath}, year={2012} }