Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis.

@article{ODonoghue2003IdentificationOF,
  title={Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis.},
  author={Keelin O'Donoghue and Mahesh Choolani and Jerry Chun-Chung Chan and Josu de la Fuente and Sailesh Kumar and Cesare Campagnoli and Phillip R. Bennett and Irene A. G. Roberts and Nicholas M Fisk},
  journal={Molecular human reproduction},
  year={2003},
  volume={9 8},
  pages={497-502}
}
Strategies for genetic prenatal diagnosis on fetal cells in the maternal circulation have been limited by lack of a cell type present only in fetal blood. However, the recent identification of mesenchymal stem cells (MSC) in first trimester fetal blood offers the prospect of targeting MSC for non-invasive prenatal diagnosis. We developed protocols for fetal MSC enrichment from maternal blood and determined sensitivity and specificity in mixing experiments of male fetal MSC added to female blood… CONTINUE READING

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