Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma.

@article{Zou2011IdentificationOE,
  title={Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma.},
  author={Libo Zou and Run-Ju Zhang and Ya-Jing Tan and Guo-Lian Ding and S. K.-Y. Shi and Dan Zhang and Rong-huan He and Xianghui Liu and Tingting Wang and Peter C. K. Leung and Jian-zhong Sheng and Hefeng Huang},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 9},
  pages={E1399-408}
}
BACKGROUND Accumulating evidence suggests that aquaporins (AQP) can facilitate cell migration, invasion, and proliferation in tumor development in addition to water transport. OBJECTIVE The aim of this study was to examine AQP2 expression in the endometrial tissues from patients with endometrial carcinoma (EC) and determine the roles and mechanisms of AQP2 in estrogen-related cell migration, invasion, adhesion, and proliferation of Ishikawa (IK) cells. APPROACH AQP2 expression levels were… CONTINUE READING
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