Identification of equine herpesvirus-1 antigens recognized by cytotoxic T lymphocytes.

@article{Soboll2003IdentificationOE,
  title={Identification of equine herpesvirus-1 antigens recognized by cytotoxic T lymphocytes.},
  author={Gisela Soboll and J. Millar Whalley and Mathew T Koen and George P Allen and Darrilyn G. Fraser and Michael D. Macklin and William F. Swain and David P. Lunn},
  journal={The Journal of general virology},
  year={2003},
  volume={84 Pt 10},
  pages={2625-34}
}
Equine herpesvirus-1 (EHV-1) causes serious disease in horses throughout the world, despite the frequent use of vaccines. CTLs are thought to be critical for protection from primary and reactivating latent EHV-1 infections. However, the antigen-specificity of EHV-1-specific CTLs is unknown. The aim of this study was to identify EHV-1 genes that encode proteins containing CTL epitopes and to determine their MHC I (or ELA-A in the horse) restriction. Equine dendritic cells, transfected with a… CONTINUE READING