Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549.

@article{Yamauchi2009IdentificationOE,
  title={Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549.},
  author={Rieko Yamauchi and Kaori Sasaki and Kenichi Yoshida},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2009},
  volume={23 5},
  pages={834-9}
}
The effects of green tea polyphenols on cultured cancer cells have been well characterized, especially the effects of epigallocatechin-3-gallate (EGCg), since EGCg suppresses oncogenic signaling pathways and induces cell cycle arrest or apoptosis by regulating cell cycle-associated proteins. In the present study, we attempted to identify signaling pathways or target molecules regulated by each of or a mixture of green tea polyphenols, including epicatechin (EC), epicatechin-3-gallate (ECg… CONTINUE READING

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