Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns.

@article{Wosikowski1997IdentificationOE,
  title={Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns.},
  author={Katja Wosikowski and Danita H. Schuurhuis and Kara M Johnson and Kenneth D. Paull and Timothy G. Myers and John N. Weinstein and Susan E Bates},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 20},
  pages={1505-15}
}
BACKGROUND Growth factor receptor-signaling pathways are potentially important targets for anticancer therapy. The interaction of anticancer agents with specific molecular targets can be identified by correlating target expression patterns with cytotoxicity patterns. We sought to identify new agents that target and inhibit the activity of the epidermal growth factor (EGF) receptor and of c-erbB2 (also called HER2 or neu), by correlating EGF receptor, transforming growth factor (TGF)-alpha (a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

Similar Papers

Loading similar papers…