Identification of endothelin receptors in various regions of rat brain.

  title={Identification of endothelin receptors in various regions of rat brain.},
  author={P. Azhahia Nambi and Mark Pullen and Giora Feuerstein},
  volume={16 4},
Endothelins (ET) are a family of 21 amino acid peptides which carry a high degree of hemology. ET-1, originally isolated from porcine endothelium in culture, is an unusually potent vasoconstrictor. Recent studies indicated the presence of ET-1 and ET-3 in the CNS, and autoradiographic evidence supported the presence of specific ET-1 binding sites. The present study aimed to raise evidence in support for the presence of ET-1 and ET-3 receptors in the rat CNS, to establish their spatial… CONTINUE READING

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