Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.

@article{Hajdu2014IdentificationOE,
  title={Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.},
  author={Zsanett Hajdu and Simon Nicolussi and M. Rau and L{\'a}szl{\'o} Lor{\'a}ntfy and P{\'e}ter Forg{\'o} and Judit Hohmann and Dezső Csupor and J{\"u}rg Gertsch},
  journal={Journal of natural products},
  year={2014},
  volume={77 7},
  pages={
          1663-9
        }
}
The discovery of the interaction of plant-derived N-alkylamides (NAAs) and the mammalian endocannabinoid system (ECS) and the existence of a plant endogenous N-acylethanolamine signaling system have led to the re-evaluation of this group of compounds. Herein, the isolation of seven NAAs and the assessment of their effects on major protein targets in the ECS network are reported. Four NAAs, octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid isobutylamide (1), octadeca-2E,4E,8E,10Z,14Z-pentaene-12… Expand
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Nine new pyr Role alkaloids, including two undescribed dimeric pyrrole 2‑carbaldehyde alkaloidal derivatives, lepipyrrolins A-B, along with three known ones (10-12) were isolated from the rhizomes of Lepidium meyenii by extensive spectroscopic data and calculated electronic circular dichroism (ECD) experiment. Expand
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