Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.

@article{Hajdu2014IdentificationOE,
  title={Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.},
  author={Z. Hajdu and S. Nicolussi and M. Rau and L. Lor{\'a}ntfy and P. Forg{\'o} and J. Hohmann and D. Csupor and J. Gertsch},
  journal={Journal of natural products},
  year={2014},
  volume={77 7},
  pages={
          1663-9
        }
}
  • Z. Hajdu, S. Nicolussi, +5 authors J. Gertsch
  • Published 2014
  • Biology, Medicine
  • Journal of natural products
  • The discovery of the interaction of plant-derived N-alkylamides (NAAs) and the mammalian endocannabinoid system (ECS) and the existence of a plant endogenous N-acylethanolamine signaling system have led to the re-evaluation of this group of compounds. Herein, the isolation of seven NAAs and the assessment of their effects on major protein targets in the ECS network are reported. Four NAAs, octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid isobutylamide (1), octadeca-2E,4E,8E,10Z,14Z-pentaene-12… CONTINUE READING
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    References

    SHOWING 1-10 OF 29 REFERENCES
    New alkamides from maca (Lepidium meyenii).
    • 81
    • PDF
    Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.
    • 47
    Alkylamides from Echinacea Are a New Class of Cannabinomimetics
    • 204
    • PDF