Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment.

  title={Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment.},
  author={Yosif M. Ganat and Elizabeth L Calder and Sonja Kriks and Jenny Nelander and Edmund Y. Tu and Fan Jia and Daniela Battista and Neil Harrison and Malin Parmar and Mark J. Tomishima and Urs Rutishauser and Lorenz Studer},
  journal={The Journal of clinical investigation},
  volume={122 8},
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA) neurons for applications in Parkinson disease. However, ESC-based transplantation paradigms carry a risk of introducing inappropriate or tumorigenic cells. Cell purification before transplantation may alleviate these concerns and enable identification of the specific DA neuron stage most suitable for cell therapy. Here, we used 3 transgenic mouse ESC reporter lines to mark DA neurons at 3 stages of… CONTINUE READING
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