Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.

Abstract

Ectodysplasin (Eda), a member of the tumor necrosis factor (Tnf) family, regulates skin appendage morphogenesis via its receptor Edar and transcription factor NF-κB. In humans, inactivating mutations in the Eda pathway components lead to hypohidrotic ectodermal dysplasia (HED), a syndrome characterized by sparse hair, tooth abnormalities, and defects in… (More)
DOI: 10.1038/jid.2011.453

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