Identification of early gene expression changes during human Th17 cell differentiation.

  title={Identification of early gene expression changes during human Th17 cell differentiation.},
  author={Soile Tuomela and Verna Salo and Subhash Tripathi and Zhi Jane Chen and Kirsti Laurila and Bhawna Gupta and Tarmo {\"A}ij{\"o} and Lotta E. Oikari and Brigitta Stockinger and Harri L{\"a}hdesm{\"a}ki and Riitta Lahesmaa},
  volume={119 23},
Th17 cells play an essential role in the pathogenesis of autoimmune and inflammatory diseases. Most of our current understanding on Th17 cell differentiation relies on studies carried out in mice, whereas the molecular mechanisms controlling human Th17 cell differentiation are less well defined. In this study, we identified gene expression changes characterizing early stages of human Th17 cell differentiation through genome-wide gene expression profiling. CD4(+) cells isolated from umbilical… CONTINUE READING
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