Identification of domains essential for the assembly of calcium/calmodulin-dependent protein kinase II holoenzymes.

@article{Kolb1998IdentificationOD,
  title={Identification of domains essential for the assembly of calcium/calmodulin-dependent protein kinase II holoenzymes.},
  author={Sylvie Kolb and Andy Hudmon and Toby Ginsberg and M. Neal Waxham},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 47},
  pages={31555-64}
}
Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), as isolated from brain, is a multimeric complex composed predominantly of two subunits, alpha and beta, products of unique genes. Little is known about how subunit composition influences holoenzyme structure or how the domain(s) of each subunit interact to form holoenzymes. We show here that holoenzymes composed of only alpha or only beta subunits exhibit different biophysical properties. The S values of alpha and beta are 17.2 and 14… CONTINUE READING

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